A new era of human protein: a new member of Proteintech HUMANKINE

Professional antibody manufacturing company Proteintech Group successfully acquired the top  human protein producer HumanZyme on April 16, 2018 in Rosemont, Ill.

HumanZyme has its own patented technology that breaks the bottleneck of human cell host expression of human protein. Its unique HumaXpress® expression system patent uses the optimized human cell HEK293, which not only provides laboratory scale, but also Large-scale GMP production  to meet  preclinical and clinical needs. HUMANKINE® is a family of highly active human proteins with natural biological functions that are free of animal and non-heterologous  protein  contamination provided by HumanZyme.

The HUMANKINE® family of human proteins has significant advantages over other host-expressed  proteins:

1. The HumaXpress® expression system creates a high expression vector that is particularly suitable  for human cells, driven by a human super-strong promoter and signal peptide, and is free  of viral  contamination. Relative to the virus drivers used by other expression systems, such as CMV and SV40, there is better security and effectiveness;

2. The expression system can mass produce a series of proteins that the bacterial host cannot express, such as the TGFβ super families;

3. It is produced by using serum-free, protein-free, chemically defined combination medium, which  can effectively avoid complex protein components in serum, such as animal albumin, animal transferrin, animal insulin and insulin-like growth factor to cells and end products. Pollution

4. The recombinant protein molecule has no label, and the proprietary purification means has fewer steps and high efficiency;

5. No heterogeneity, no animal origin, ultra low endotoxin, high purity, no other protein carrier (such as BSA);

6. It has true post-translational modification  and correct folding such as  glycosylation and  phosphorylation, resulting in high biological activity, long half-life and high stability in vitro;

7. Widely used in stem cells, neurobiology, immunology, apoptosis, protein drugs, and regenerative medicine and cell biological therapy.

Through this acquisition, the Proteintech Group has further consolidated its position as a well-known manufacturer of antibodies, proteins and ELISA kits.