Introduction
Results
From activation to inhibition: the proof of concept
a
a
Integrated (iterative) approach for hit-to-lead optimization
Compound optimization studies by the TSA, enzymatic assay, X-ray crystallography and cellular assay
Nucleotide insufficiency promotes DNA damage and cell death
Successful synthetic lethality in a T-ALL mouse model
a
Predicting sensitivity using T-ALL patient-derived xenograft models
a