Introduction
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Results
Fabrication and characterization of gas nanoadjuvant
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Assessment of H 2S generation and drug release
Photothermal performance and production of ROS and CO
Cellular uptake
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Intracellular H 2S/CO generation and mitochondrial dysfunction
H2
mtDNA release and cGAS-STING pathway stimulation
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In vitro cytotoxicity and apoptosis assay
Multimodal imaging
In vivo anticancer study
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cGAS-STING pathway activation and antitumor immune responses
Abscopal effect in bilateral tumor model
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Discussion
In recent years, diverse efforts have been devoted to eliminating tumors through the nanomaterial-based combination of phototherapy and gas therapy65,66