Introduction
In this study, we examined breast tumors profiled with TBx and LBx comprehensive genomic profiling (CGP) as part of routine clinical care to characterize the diversity of acquired mutations and their associations with therapeutic interventions in a real-world setting (Fig. 1).
Results
Mutational spectrum of breast tumors profiled with tissue and liquid biopsy
a
712 patients with longitudinal TBx and LBx profiling reveal a spectrum of acquired tumor resistance mechanisms and actionable targets
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Acquired alterations are associated with therapeutic intervention
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Case 1
Case 2
Case 3
Discussion
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