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 The immune checkpoint VISTA exhibits high expression levels in human gliomas and associates with a p AbstractIn human gliomas, anti-tumor T cell responses are inhibited through induction of local and systemic immunosuppression. Immune checkpoint blockade is proving to be a success in several types... |
 AbstractCardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Endothelial cell (EC) dysfunction is a key CKD-specific risk factor; however, the m... |
 AbstractAccumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 re... |
 AbstractThe aim of this study was to present and evaluate novel oral vaccines, based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRN... |
 Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis- AbstractNecrotic cell death represents a major pathogenic mechanism of Mycobacterium tuberculosis(Mtb) infection. It is increasingly evident that Mtb induces several types of regulated necrosis but... |
 TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppre AbstractTumor necrosis factor (TNF)-α-induced protein 8-like 2 (TIPE2) is a newly discovered negative immunoregulatory protein that is involved in various cellular immune responses to infections. H... |
 A preliminary study of KAT2A on cGAS-related immunity in inflammation amplification of systemic lupu AbstractPrevious studies demonstrated that cGAS pathway is related to the inflammation amplification in a variety of autoimmune diseases. Lysine acetyltransferase family (KATs) can regulate the nuc... |
 AbstractThe autosomal dominant monogenetic disease neurofibromatosis type 1 (NF1) affects approximately one in 3,000 individuals and is caused by mutations in the NF1 tumour suppressor gene, leadin... |
 Daily caloric restriction limits tumor growth more effectively than caloric cycling regardless of di AbstractCancer incidence increases with age and is a leading cause of death. Caloric restriction (CR) confers benefits on health and survival and delays cancer. However, due to CR’s stringency, die... |
 Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metas AbstractPre-metastatic niche formation is critical for the colonization of disseminated cancer cells in distant organs. Here we find that lung mesenchymal stromal cells (LMSCs) at pre-metastatic st... |
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