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 IL-37 isoform D acts as an inhibitor of soluble ST2 to boost type 2 immune homeostasis in white adip AbstractWhite adipose tissue (WAT) homeostasis substantiated by type 2 immunity is indispensable to counteract obesity and metabolic disorders. IL-33/suppression of tumorigenicity (ST) 2 signaling ... |
 AbstractThe air-filled organs (AOs) of vertebrates (lungs and swim bladders) have evolved unique functions (air-breathing or buoyancy control in water) to adapt to different environments. Thus far,... |
 Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying AbstractTrans-chromosomic (Tc) mice carrying mini-chromosomes with megabase-sized human immunoglobulin (Ig) loci have contributed to the development of fully human therapeutic monoclonal antibodies... |
 AbstractPUMILIO (PUM) proteins belong to the highly conserved PUF family post-transcriptional regulators involved in diverse biological processes. However, their function in carcinogenesis remains ... |
 Single-cell transcriptomic analysis suggests two molecularly subtypes of intrahepatic cholangiocarci AbstractIntrahepatic cholangiocarcinoma (iCCA) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment. Here, by performing single-cell RNA sequ... |
 Trade-off between reducing mutational accumulation and increasing commitment to differentiation dete AbstractSpecies-specific differences control cancer risk across orders of magnitude variation in body size and lifespan, e.g., by varying the copy numbers of tumor suppressor genes. It is unclear, ... |
 Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-s AbstractResistance to EGFR inhibitors (EGFRi) presents a major obstacle in treating non-small cell lung cancer (NSCLC). One of the most exciting new ways to find potential resistance markers involv... |
 AbstractHydrogen sulfide (H2S) as an important biological gasotransmitter plays a pivotal role in many physiological and pathological processes. The sensitive and quantitative detection of H2S leve... |
 AbstractThe mesothelium lines body cavities and surrounds internal organs, widely contributing to homeostasis and regeneration. Mesothelium disruptions cause visceral anomalies and mesothelioma tum... |
 AbstractDevimistat is a TCA cycle inhibitor. A previously completed phase I study of devimistat in combination with cytarabine and mitoxantrone in patients with relapsed or refractory AML showed pr... |
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