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 AbstractEctodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular cyclic guanosine monophosphate ... |
 Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MY AbstractCircular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well underst... |
 The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamou AbstractEsophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape... |
 Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in re AbstractMolecular routes to metastatic dissemination are critical determinants of aggressive cancers. Through in vivo CRISPR–Cas9 genome editing, we generated somatic mosaic genetically engineered ... |
 Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marr AbstractMetastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the m... |
 Chimeric antigen receptor T cells targeting FcRH5 provide robust tumour-specific responses in murine AbstractBCMA-targeting chimeric antigen receptor (CAR) T cell therapy demonstrates impressive clinical response in multiple myeloma (MM). However, some patients with BCMA-deficient tumours cannot b... |
 AbstractThe cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT) protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we report a surpr... |
 Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heteroge AbstractTwo tumor (Classical/Basal) and stroma (Inactive/active) subtypes of Pancreatic adenocarcinoma (PDAC) with prognostic and theragnostic implications have been described. These molecular subt... |
 Directed natural evolution generates a next-generation oncolytic virus with a high potency and safet AbstractOncolytic viruses (OVs) represent a type of encouraging multi-mechanistic drug for the treatment of cancer. However, attenuation of virulence, which is generally required for the developmen... |
 AbstractThe success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and s... |
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